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Our newsletter appears once every two months and reports about new and improved products. In addition, it contains news and announcements from MRC-Holland, among others information on upcoming workshops, recently identified problems associated with the use of MLPA, new publications and calls for testing new products.

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MRC-Holland newsletter 2017 November snapshot


News & Events


Unsuitability of HhaI from Thermo Fisher Scientific, and possibly other suppliers, for MS-MLPA
17 November 2016

We have established that HhaI restriction enzymes manufactured by Thermo Fisher Scientific are incompatible with the MS-MLPA technique and can cause aberrant results as they are not inactivated by heat. The same may be true for certain HhaI (isoschizomers) from other suppliers. At this moment, the only restriction enzyme with proven suitability for MS- MLPA is the Promega (R6441) enzyme. Please find more information here.

Come and meet us

If you are attending one of the following meetings, please stop by our booth to learn more about how MLPA can be used to benefit your DNA, RNA or methylation analysis.

November 16-18 - AMP, Salt Lake City, UT, United States (stand #410).

MRC-Holland booth at a congress
The upcoming MLPA workshops organised by MRC-Holland are listed here.
new products
P420-MPN mix 1
Myeloproliferative neoplasms
P475-FOXP1 - FOXP2
mental retardation
improved products
P241-MODY Mix 1
Maturity-Onset Diabetes of the Young (MODY)
P374-Microdeletion-8
Microdeletion follow-up: 7q11, PWS/AS, Miller-Dieker, Smith-Magenis, RETT
P077-BRCA2 Confirmation
Breast cancer, hereditary
P318-Hirschsprung-2
Hirschsprung disease
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